Pre-treated Populus tomentiglandulosa extract inhibits neuronal loss and alleviates gliosis in the gerbil hippocampal CA1 area induced by transient global cerebral ischemia.
Identifieur interne : 001244 ( Main/Exploration ); précédent : 001243; suivant : 001245Pre-treated Populus tomentiglandulosa extract inhibits neuronal loss and alleviates gliosis in the gerbil hippocampal CA1 area induced by transient global cerebral ischemia.
Auteurs : Joon Ha Park [Corée du Sud] ; Tae-Kyeong Lee [Corée du Sud] ; Ji Hyeon Ahn [Corée du Sud] ; Bich-Na Shin [Corée du Sud] ; Jeong Hwi Cho [Corée du Sud] ; In Hye Kim [Corée du Sud] ; Jae-Chul Lee [Corée du Sud] ; Jong-Dai Kim [Corée du Sud] ; Young Joo Lee [Corée du Sud] ; Il Jun Kang [Corée du Sud] ; Seongkweon Hong [Corée du Sud] ; Yang Hee Kim [Corée du Sud] ; Yong Hwan Jeon [Corée du Sud] ; Yun Lyul Lee [Corée du Sud] ; Moo-Ho Won [Corée du Sud]Source :
- Anatomy & cell biology [ 2093-3665 ] ; 2017.
Abstract
The genus Populus (poplar) belonging to the Salicaceae family has been used in traditional medicine, and its several species show various pharmacological properties including antioxidant and anti-inflammatory effects. No study regarding protective effects of Populus species against cerebral ischemia has been reported. Therefore, in the present study, we examined neuroprotective effects of ethanol extract from Populus tomentiglandulosa (Korea poplar) in the hippocampal cornu ammonis (CA1) area of gerbils subjected to 5 minutes of transient global cerebral ischemia. Pretreatment with 200 mg/kg of P. tomentiglandulosa extract effectively protected CA1 pyramidal neurons from transient global cerebral ischemia. In addition, glial fibrillary acidic protein immunoreactive astrocytes and ionized calcium binding adapter molecule 1 immunoreactive microglia were significantly diminished in the ischemic CA1 area by pretreatment with 200 mg/kg of P. tomentiglandulosa extract. Briefly, our results indicate that pretreatment with P. tomentiglandulosa extract protects neurons from transient cerebral ischemic injury and diminish cerebral ischemia-induced reactive gliosis in ischemic CA1 area. Based on these results, we suggest that P. tomentiglandulosa can be used as a potential candidate for prevention of ischemic injury.
DOI: 10.5115/acb.2017.50.4.284
PubMed: 29354300
PubMed Central: PMC5768565
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pre-treated <i>Populus tomentiglandulosa</i> extract inhibits neuronal loss and alleviates gliosis in the gerbil hippocampal CA1 area induced by transient global cerebral ischemia.</title><author><name sortKey="Park, Joon Ha" sort="Park, Joon Ha" uniqKey="Park J" first="Joon Ha" last="Park">Joon Ha Park</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Tae Kyeong" sort="Lee, Tae Kyeong" uniqKey="Lee T" first="Tae-Kyeong" last="Lee">Tae-Kyeong Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Ahn, Ji Hyeon" sort="Ahn, Ji Hyeon" uniqKey="Ahn J" first="Ji Hyeon" last="Ahn">Ji Hyeon Ahn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Shin, Bich Na" sort="Shin, Bich Na" uniqKey="Shin B" first="Bich-Na" last="Shin">Bich-Na Shin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Cho, Jeong Hwi" sort="Cho, Jeong Hwi" uniqKey="Cho J" first="Jeong Hwi" last="Cho">Jeong Hwi Cho</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, In Hye" sort="Kim, In Hye" uniqKey="Kim I" first="In Hye" last="Kim">In Hye Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Jae Chul" sort="Lee, Jae Chul" uniqKey="Lee J" first="Jae-Chul" last="Lee">Jae-Chul Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jong Dai" sort="Kim, Jong Dai" uniqKey="Kim J" first="Jong-Dai" last="Kim">Jong-Dai Kim</name><affiliation wicri:level="1"><nlm:affiliation>Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Young Joo" sort="Lee, Young Joo" uniqKey="Lee Y" first="Young Joo" last="Lee">Young Joo Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Emergency Medicine, Sooncheonhyang University Seoul Hospital, Sooncheonhyang University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Emergency Medicine, Sooncheonhyang University Seoul Hospital, Sooncheonhyang University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kang, Il Jun" sort="Kang, Il Jun" uniqKey="Kang I" first="Il Jun" last="Kang">Il Jun Kang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Food Science and Nutrition, Hallym University, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Food Science and Nutrition, Hallym University, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Hong, Seongkweon" sort="Hong, Seongkweon" uniqKey="Hong S" first="Seongkweon" last="Hong">Seongkweon Hong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Surgery, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Yang Hee" sort="Kim, Yang Hee" uniqKey="Kim Y" first="Yang Hee" last="Kim">Yang Hee Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Surgery, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Jeon, Yong Hwan" sort="Jeon, Yong Hwan" uniqKey="Jeon Y" first="Yong Hwan" last="Jeon">Yong Hwan Jeon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Radiology, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Yun Lyul" sort="Lee, Yun Lyul" uniqKey="Lee Y" first="Yun Lyul" last="Lee">Yun Lyul Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physiology and Institute of Neurodegeneration and Neuroregeneration, Hallym University College of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Physiology and Institute of Neurodegeneration and Neuroregeneration, Hallym University College of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Won, Moo Ho" sort="Won, Moo Ho" uniqKey="Won M" first="Moo-Ho" last="Won">Moo-Ho Won</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29354300</idno><idno type="pmid">29354300</idno><idno type="doi">10.5115/acb.2017.50.4.284</idno><idno type="pmc">PMC5768565</idno><idno type="wicri:Area/Main/Corpus">000F98</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000F98</idno><idno type="wicri:Area/Main/Curation">000F98</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000F98</idno><idno type="wicri:Area/Main/Exploration">000F98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pre-treated <i>Populus tomentiglandulosa</i> extract inhibits neuronal loss and alleviates gliosis in the gerbil hippocampal CA1 area induced by transient global cerebral ischemia.</title><author><name sortKey="Park, Joon Ha" sort="Park, Joon Ha" uniqKey="Park J" first="Joon Ha" last="Park">Joon Ha Park</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Tae Kyeong" sort="Lee, Tae Kyeong" uniqKey="Lee T" first="Tae-Kyeong" last="Lee">Tae-Kyeong Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Ahn, Ji Hyeon" sort="Ahn, Ji Hyeon" uniqKey="Ahn J" first="Ji Hyeon" last="Ahn">Ji Hyeon Ahn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Shin, Bich Na" sort="Shin, Bich Na" uniqKey="Shin B" first="Bich-Na" last="Shin">Bich-Na Shin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Cho, Jeong Hwi" sort="Cho, Jeong Hwi" uniqKey="Cho J" first="Jeong Hwi" last="Cho">Jeong Hwi Cho</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, In Hye" sort="Kim, In Hye" uniqKey="Kim I" first="In Hye" last="Kim">In Hye Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Jae Chul" sort="Lee, Jae Chul" uniqKey="Lee J" first="Jae-Chul" last="Lee">Jae-Chul Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jong Dai" sort="Kim, Jong Dai" uniqKey="Kim J" first="Jong-Dai" last="Kim">Jong-Dai Kim</name><affiliation wicri:level="1"><nlm:affiliation>Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Young Joo" sort="Lee, Young Joo" uniqKey="Lee Y" first="Young Joo" last="Lee">Young Joo Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Emergency Medicine, Sooncheonhyang University Seoul Hospital, Sooncheonhyang University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Emergency Medicine, Sooncheonhyang University Seoul Hospital, Sooncheonhyang University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kang, Il Jun" sort="Kang, Il Jun" uniqKey="Kang I" first="Il Jun" last="Kang">Il Jun Kang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Food Science and Nutrition, Hallym University, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Food Science and Nutrition, Hallym University, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Hong, Seongkweon" sort="Hong, Seongkweon" uniqKey="Hong S" first="Seongkweon" last="Hong">Seongkweon Hong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Surgery, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Yang Hee" sort="Kim, Yang Hee" uniqKey="Kim Y" first="Yang Hee" last="Kim">Yang Hee Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Surgery, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Jeon, Yong Hwan" sort="Jeon, Yong Hwan" uniqKey="Jeon Y" first="Yong Hwan" last="Jeon">Yong Hwan Jeon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Radiology, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Yun Lyul" sort="Lee, Yun Lyul" uniqKey="Lee Y" first="Yun Lyul" last="Lee">Yun Lyul Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physiology and Institute of Neurodegeneration and Neuroregeneration, Hallym University College of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Physiology and Institute of Neurodegeneration and Neuroregeneration, Hallym University College of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Won, Moo Ho" sort="Won, Moo Ho" uniqKey="Won M" first="Moo-Ho" last="Won">Moo-Ho Won</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author></analytic><series><title level="j">Anatomy & cell biology</title><idno type="ISSN">2093-3665</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The genus <i>Populus</i> (poplar) belonging to the Salicaceae family has been used in traditional medicine, and its several species show various pharmacological properties including antioxidant and anti-inflammatory effects. No study regarding protective effects of <i>Populus</i> species against cerebral ischemia has been reported. Therefore, in the present study, we examined neuroprotective effects of ethanol extract from <i>Populus tomentiglandulosa</i> (Korea poplar) in the hippocampal cornu ammonis (CA1) area of gerbils subjected to 5 minutes of transient global cerebral ischemia. Pretreatment with 200 mg/kg of <i>P. tomentiglandulosa</i> extract effectively protected CA1 pyramidal neurons from transient global cerebral ischemia. In addition, glial fibrillary acidic protein immunoreactive astrocytes and ionized calcium binding adapter molecule 1 immunoreactive microglia were significantly diminished in the ischemic CA1 area by pretreatment with 200 mg/kg of <i>P. tomentiglandulosa</i> extract. Briefly, our results indicate that pretreatment with <i>P. tomentiglandulosa</i> extract protects neurons from transient cerebral ischemic injury and diminish cerebral ischemia-induced reactive gliosis in ischemic CA1 area. Based on these results, we suggest that <i>P. tomentiglandulosa</i> can be used as a potential candidate for prevention of ischemic injury.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">29354300</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2093-3665</ISSN><JournalIssue CitedMedium="Print"><Volume>50</Volume><Issue>4</Issue><PubDate><Year>2017</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Anatomy & cell biology</Title><ISOAbbreviation>Anat Cell Biol</ISOAbbreviation></Journal><ArticleTitle>Pre-treated <i>Populus tomentiglandulosa</i> extract inhibits neuronal loss and alleviates gliosis in the gerbil hippocampal CA1 area induced by transient global cerebral ischemia.</ArticleTitle><Pagination><MedlinePgn>284-292</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.5115/acb.2017.50.4.284</ELocationID><Abstract><AbstractText>The genus <i>Populus</i> (poplar) belonging to the Salicaceae family has been used in traditional medicine, and its several species show various pharmacological properties including antioxidant and anti-inflammatory effects. No study regarding protective effects of <i>Populus</i> species against cerebral ischemia has been reported. Therefore, in the present study, we examined neuroprotective effects of ethanol extract from <i>Populus tomentiglandulosa</i> (Korea poplar) in the hippocampal cornu ammonis (CA1) area of gerbils subjected to 5 minutes of transient global cerebral ischemia. Pretreatment with 200 mg/kg of <i>P. tomentiglandulosa</i> extract effectively protected CA1 pyramidal neurons from transient global cerebral ischemia. In addition, glial fibrillary acidic protein immunoreactive astrocytes and ionized calcium binding adapter molecule 1 immunoreactive microglia were significantly diminished in the ischemic CA1 area by pretreatment with 200 mg/kg of <i>P. tomentiglandulosa</i> extract. Briefly, our results indicate that pretreatment with <i>P. tomentiglandulosa</i> extract protects neurons from transient cerebral ischemic injury and diminish cerebral ischemia-induced reactive gliosis in ischemic CA1 area. Based on these results, we suggest that <i>P. tomentiglandulosa</i> can be used as a potential candidate for prevention of ischemic injury.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Joon Ha</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Tae-Kyeong</ForeName><Initials>TK</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahn</LastName><ForeName>Ji Hyeon</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shin</LastName><ForeName>Bich-Na</ForeName><Initials>BN</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cho</LastName><ForeName>Jeong Hwi</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>In Hye</ForeName><Initials>IH</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jae-Chul</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Jong-Dai</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Young Joo</ForeName><Initials>YJ</Initials><AffiliationInfo><Affiliation>Department of Emergency Medicine, Sooncheonhyang University Seoul Hospital, Sooncheonhyang University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Il Jun</ForeName><Initials>IJ</Initials><AffiliationInfo><Affiliation>Department of Food Science and Nutrition, Hallym University, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hong</LastName><ForeName>Seongkweon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Surgery, Kangwon National University School of Medicine, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Yang Hee</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>Department of Surgery, Kangwon National University School of Medicine, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeon</LastName><ForeName>Yong Hwan</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>Department of Radiology, Kangwon National University School of Medicine, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Yun Lyul</ForeName><Initials>YL</Initials><AffiliationInfo><Affiliation>Department of Physiology and Institute of Neurodegeneration and Neuroregeneration, Hallym University College of Medicine, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Won</LastName><ForeName>Moo-Ho</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, Kangwon National University School of Medicine, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>12</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>Korea (South)</Country><MedlineTA>Anat Cell Biol</MedlineTA><NlmUniqueID>101531987</NlmUniqueID><ISSNLinking>2093-3665</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Neuronal death</Keyword><Keyword MajorTopicYN="N">Neuroprotective effects</Keyword><Keyword MajorTopicYN="N">Populus tomentiglandulosa</Keyword><Keyword MajorTopicYN="N">Reactive gliosis</Keyword><Keyword MajorTopicYN="N">Transient global cerebral ischemia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>07</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>08</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>08</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>1</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>1</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>1</Month><Day>23</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29354300</ArticleId><ArticleId 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du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Park, Joon Ha" sort="Park, Joon Ha" uniqKey="Park J" first="Joon Ha" last="Park">Joon Ha Park</name></noRegion><name sortKey="Ahn, Ji Hyeon" sort="Ahn, Ji Hyeon" uniqKey="Ahn J" first="Ji Hyeon" last="Ahn">Ji Hyeon Ahn</name><name sortKey="Cho, Jeong Hwi" sort="Cho, Jeong Hwi" uniqKey="Cho J" first="Jeong Hwi" last="Cho">Jeong Hwi Cho</name><name sortKey="Hong, Seongkweon" sort="Hong, Seongkweon" uniqKey="Hong S" first="Seongkweon" last="Hong">Seongkweon Hong</name><name sortKey="Jeon, Yong Hwan" sort="Jeon, Yong Hwan" uniqKey="Jeon Y" first="Yong Hwan" last="Jeon">Yong Hwan Jeon</name><name sortKey="Kang, Il Jun" sort="Kang, Il Jun" uniqKey="Kang I" first="Il Jun" last="Kang">Il Jun Kang</name><name sortKey="Kim, In Hye" sort="Kim, In Hye" uniqKey="Kim I" first="In Hye" last="Kim">In Hye Kim</name><name sortKey="Kim, Jong Dai" sort="Kim, Jong Dai" uniqKey="Kim J" first="Jong-Dai" last="Kim">Jong-Dai Kim</name><name sortKey="Kim, Yang Hee" sort="Kim, Yang Hee" uniqKey="Kim Y" first="Yang Hee" last="Kim">Yang Hee Kim</name><name sortKey="Lee, Jae Chul" sort="Lee, Jae Chul" uniqKey="Lee J" first="Jae-Chul" last="Lee">Jae-Chul Lee</name><name sortKey="Lee, Tae Kyeong" sort="Lee, Tae Kyeong" uniqKey="Lee T" first="Tae-Kyeong" last="Lee">Tae-Kyeong Lee</name><name sortKey="Lee, Young Joo" sort="Lee, Young Joo" uniqKey="Lee Y" first="Young Joo" last="Lee">Young Joo Lee</name><name sortKey="Lee, Yun Lyul" sort="Lee, Yun Lyul" uniqKey="Lee Y" first="Yun Lyul" last="Lee">Yun Lyul Lee</name><name sortKey="Shin, Bich Na" sort="Shin, Bich Na" uniqKey="Shin B" first="Bich-Na" last="Shin">Bich-Na Shin</name><name sortKey="Won, Moo Ho" sort="Won, Moo Ho" uniqKey="Won M" first="Moo-Ho" last="Won">Moo-Ho Won</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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